BDBM50240514 (3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine::(Z)-2-Chloro-9-(omega-dimethylaminopropylidene)thioxanthene::(Z)-chlorprothixene::CHEMBL908::CHLORPROTHIXENE::cis-2-Chloro-9-(3-dimethylaminopropylidene)thioxanthene
SMILES CN(C)CC\C=C1\c2ccccc2Sc2ccc(Cl)cc12
InChI Key InChIKey=WSPOMRSOLSGNFJ-AUWJEWJLSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50240514
TargetD(2) dopamine receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T
Curated by ChEMBL
Johann Wolfgang Goethe Universit£T
Curated by ChEMBL
Affinity DataKi: 2.96nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T
Curated by ChEMBL
Johann Wolfgang Goethe Universit£T
Curated by ChEMBL
Affinity DataKi: 3.75nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T
Curated by ChEMBL
Johann Wolfgang Goethe Universit£T
Curated by ChEMBL
Affinity DataKi: 4.56nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataKi: 5.60nMAssay Description:Binding affinity towards rat 5-hydroxytryptamine 7 receptorMore data for this Ligand-Target Pair
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T
Curated by ChEMBL
Johann Wolfgang Goethe Universit£T
Curated by ChEMBL
Affinity DataKi: 9nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T
Curated by ChEMBL
Johann Wolfgang Goethe Universit£T
Curated by ChEMBL
Affinity DataKi: 18nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T
Curated by ChEMBL
Johann Wolfgang Goethe Universit£T
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 7.78E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
Affinity DataIC50: 1.07nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T
Curated by ChEMBL
Johann Wolfgang Goethe Universit£T
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
TargetHistamine H1 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T
Curated by ChEMBL
Johann Wolfgang Goethe Universit£T
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
TargetPleiotropic ABC efflux transporter of multiple drugs(Saccharomyces cerevisiae S288c)
Wroclaw Medical University
Curated by ChEMBL
Wroclaw Medical University
Curated by ChEMBL
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.75E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Federal University Of Parana
Curated by ChEMBL
Federal University Of Parana
Curated by ChEMBL
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of human ABCG2 expressed in human SAOS-2 cells mediated mitoxantrone efflux using mitoxantrone as substrate by flow cytometryMore data for this Ligand-Target Pair